Hydrogen Bromide → HCID 20242536, compound

Participants

Reaction Steps

A solution of 1-(4-chlorophenyl)-3-dimethylamino-6,7-dimethoxy-1,4-dihydroisoquinoline hydrochloride (1.3 g) in 48% aqueous hydrobromic acid (100 ml) was heated at 100°-120° C. under nitrogen for 3 h. The hot solution was filtered, and the filtrate evaporated to dryness in vacuo and recrystallised from ethanol-ether, to give 1-(4-chlorophenyl)-6,7-dihydroxy-3-dimethylamino-1,4-dihydroisoquinoline hydrobromide (1.07 g), m.p. 232°-235° C.

Provenance & Evidence