Hydrogen Bromide → HCID 20242536, compound

HRID 483145Notes

Reaction equation

HRID 483145 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[C:18]3[C:13](=[CH:14][C:15]([O:21]C)=[C:16]([O:19]C)[CH:17]=3)[CH2:12][C:11]([N:23]([CH3:25])[CH3:24])=[N:10]2)=[CH:5][CH:4]=1.[BrH:26]>>[BrH:26].[Cl:2][C:3]1[CH:4]=[CH:5][C:6]([CH:9]2[C:18]3[C:13](=[CH:14][C:15]([OH:21])=[C:16]([OH:19])[CH:17]=3)[CH2:12][C:11]([N:23]([CH3:25])[CH3:24])=[N:10]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 20242545HCID 20242545, compound

Product 1

HCID 20242536HCID 20242536, compound

Procedure

A solution of 1-(4-chlorophenyl)-3-dimethylamino-6,7-dimethoxy-1,4-dihydroisoquinoline hydrochloride (1.3 g) in 48% aqueous hydrobromic acid (100 ml) was heated at 100°-120° C. under nitrogen for 3 h. The hot solution was filtered, and the filtrate evaporated to dryness in vacuo and recrystallised from ethanol-ether, to give 1-(4-chlorophenyl)-6,7-dihydroxy-3-dimethylamino-1,4-dihydroisoquinoline hydrobromide (1.07 g), m.p. 232°-235° C.

Workup

  1. filtrationThe hot solution was filtered
  2. customthe filtrate evaporated to dryness in vacuo
  3. customrecrystallised from ethanol-ether

Sources & evidence

ORD record
ord-f03ce749360841b6a74a9c2113a94277
Source dataset
uspto-grants-1986_03
Patent number
US04578393

Reaction notes

Loading…