反应详情

2 Grams of 5-carboxycarbostyril was suspended in 100 ml of methanol, and hydrogen chloride gas was saturated by bubbling into this suspension, then the reaction mixture was refluxed for 3 hours. The reaction mixture was concentrated to be reduced one-half volume of its initial value, and the precipitated crystals were collected by filtration. The crystals were purified by a silica gel column chromatography, and recrystallized from methanol-chloroform to obtain 230 mg of 5-methoxycarbonylcarbostyril in the form of colorless powdery product.

1. customby bubbling into this suspension
2. temperaturethe reaction mixture was refluxed for 3 hours
3. concentrationThe reaction mixture was concentrated
4. filtrationthe precipitated crystals were collected by filtration
5. customThe crystals were purified by a silica gel column chromatography
6. customrecrystallized from methanol-chloroform