反应详情

To 5 g of 3-hydroxymethylcarbostyril was added 50 ml of 47%-hydrobromic acid and the mixture was stirred at 70°-80° C. for 3 hours. After cooled the reaction mixture, the crystals precipitated were collected by filtration and were recrystallized from methanol to obtain 6 g of 3-bromomethylcarbostyril in the form of colorless needle-like crystals.

1. temperatureAfter cooled the reaction mixture
2. customthe crystals precipitated
3. filtrationwere collected by filtration
4. customwere recrystallized from methanol