HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(Chloromethyl)-1,2-dihydroquinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Chloro-3-(chloromethyl)quinoline | HCID 2063384 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-(Chloromethyl)-1,2-dihydroquinolin-2-one | HCID 13342169 | — |
Reaction Steps
2.8 Grams of 2-chloro-3-chloromethylquinoline was dissolved in 30 ml of acetic acid and the solution was refluxed for 2 hours. The reaction mixture was poured into water and the crystals precipitated were collected by filtration, and were recrystallized from methanol to obtain 2.1 g of 3-chloromethylcarbostyril in the form of colorless needle-like crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04578381 |
| Source dataset | uspto-grants-1986_03 |
| ORD ID | ord-1b696b25ffa841849677199997dd31d1 |
| Source note | uspto-grants-1986_03 |