Hydrochloric Acid → 2-Aminobenzaldehyde

In a four-necked flask, there were placed 175 ml of water, 10.5 g of ferrous sulfate heptahydrate, 0.5 ml of concentrated hydrochloric acid and 6 g of o-nitrobenzaldehyde, then the flask was heated at 90° C. on a water-bath. Into the reaction mixture in the flask, 25 ml of a concentrated ammonia water was added in one-time with stirring, further 30 ml of ammonia water was added in three times in every 2 minutes. After finished the addition of ammonia water, the reaction mixture was subjected to steam distillation immediately. The distillate in an amount of 250 ml was collected in two times separately. The first distillate was cooled and the crystals precipitated were collected by filtration. The mother liquor obtained from the first distillate was combined with second distillate, and this mixture was saturated with sodium chloride, then was extracted with ether extract was dried with sodium sulfate, and ether was removed by distillation. The residue thus obtained was combined with the crystals precipitated from the first distillate and the mixture was dried to obtain 2.9 g of o-aminobenzaldehyde in the form of yellowish flake-like crystals.

1. customIn a four-necked flask, there were placed
2. distillationthe reaction mixture was subjected to steam distillation immediately
3. distillationThe distillate in an amount of 250 ml was collected in two times separately
4. temperatureThe first distillate was cooled
5. customthe crystals precipitated
6. filtrationwere collected by filtration
7. customThe mother liquor obtained from the first distillate
8. extractionwas extracted with ether
9. extractionextract
10. dry with materialwas dried with sodium sulfate, and ether
11. customwas removed by distillation
12. customThe residue thus obtained
13. customprecipitated from the first distillate
14. customthe mixture was dried

ORD record

ord-381e34a57e5f4bebaf4e780401ea5d8f

Source dataset

uspto-grants-1986_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04578381