Hydrochloric Acid → HCID 16218315, compound

HRID 483174Notes

Reaction equation

HRID 483174 reaction equation
C([NH:4][C:5](C(O)=O)([CH2:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[NH:15][C:14](=[O:22])[CH:13]=1)[C:6]([O:8]CC)=[O:7])(=[O:3])C.[ClH:26]>>[OH2:3].[ClH:26].[NH2:4][CH:5]([CH2:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[NH:15][C:14](=[O:22])[CH:13]=1)[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 131714591HCID 131714591, compound

Product 1

HCID 16218315HCID 16218315, compound

Procedure

To 5 g of ethy 2-acetamido-2-carboxy-3-(2-quinolon-4-yl)propionate was added 150 ml of 20%-hydrochloric acid and the mixture was refluxed for 9 hours. The reaction mixture was concentrated under a reduced pressure, the residue was recrystallized from ethanon-water to obtain 3.2 g of 2-amino-3-(2-quinolon-4-yl)propionic acid hydrochloride hydrate in the form of folorless prism-like crystals.

Workup

  1. temperaturethe mixture was refluxed for 9 hours
  2. concentrationThe reaction mixture was concentrated under a reduced pressure
  3. customthe residue was recrystallized from ethanon-water

Sources & evidence

ORD record
ord-ae24fc08d6854e38b40b83b3610e5aa3
Source dataset
uspto-grants-1986_03
Patent number
US04578381

Reaction notes

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