Hydrochloric Acid → HCID 13342158, compound

HRID 483182Notes

Reaction equation

HRID 483182 reaction equation
[CH3:1][O:2][C:3]1[CH:27]=[CH:26][C:6]([C:7]([NH:9][CH:10]([CH2:14][C:15]2[C:16](=[O:25])[NH:17][C:18]3[C:23]([CH:24]=2)=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:11]([OH:13])=[O:12])=[O:8])=[CH:5][CH:4]=1.Cl.[CH2:29](O)[CH3:30]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:9][CH:10]([CH2:14][C:15]2[C:16](=[O:25])[NH:17][C:18]3[C:23]([CH:24]=2)=[CH:22][CH:21]=[CH:20][CH:19]=3)[C:11]([O:13][CH2:29][CH3:30])=[O:12])=[O:8])=[CH:26][CH:27]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 13342106HCID 13342106, compound

Product 1

HCID 13342158HCID 13342158, compound

Procedure

1.8 Grams of 2-(4-methoxybenzoyl)amino-3-(2-quinolon-3yl)propionic acid was dissolved in 100 ml of ethanol, then to this solution was introduced and saturated with hydrogen chloride gas under an ice-cooled condition with stirring. The reaction mixture was then refluxed for 5 hours and after completion of the reaction, the solvent was removed by distillation under a reduced pressure, the residue obtained was recrystallized from ethyl acetate-ethanol to obtain 1.5 g of ethyl 2-(4-methoxybenzoyl)amino-3-(2-quinolon-3-yl)propionate in the form of white powder product.

Workup

  1. temperaturecooled condition
  2. temperatureThe reaction mixture was then refluxed for 5 hours
  3. customafter completion of the reaction
  4. customthe solvent was removed by distillation under a reduced pressure
  5. customthe residue obtained
  6. customwas recrystallized from ethyl acetate-ethanol

Sources & evidence

ORD record
ord-235c3b42058d4e918e9e9724f8b73266
Source dataset
uspto-grants-1986_03
Patent number
US04578381

Reaction notes

Loading…