HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-aminocrotonate → HCID 11755183, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | 54527-73-0 | HCID 12529188 | — |
| Reactant | 2-Chloro-3-fluorobenzaldehyde | HCID 14944905 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 11755183 | HCID 11755183 | 60.9% |
Reaction Steps
A mixture of 460 mg of 2-chloro-3-fluorobenzaldehyde, 360 mg of methyl 3-aminocrotonate and 820 mg of 2-(N-benzyl-N-methylamino)ethyl 3-aminocrotonate in 4 ml of 2-propanol was refluxed for 8 hours, and then the solvent was distilled off under reduced pressure. The residue was purified by a column chromatography on silica gel to provide 860 mg of the desired compound (110).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04578395 |
| Source dataset | uspto-grants-1986_03 |
| ORD ID | ord-5f62400733ab4d17b55942c6f710d863 |
| Source note | uspto-grants-1986_03 |