HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 3-aminocrotonate → 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(2-fluoro-5-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 3-aminocrotonate | HCID 643918 | — |
| Reactant | 2-Fluoro-5-nitrobenzaldehyde | HCID 2734770 | — |
| Reactant | 2-(Benzylmethylamino)ethyl acetoacetate | HCID 11776829 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(2-fluoro-5-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | HCID 10051569 | 40% |
Reaction Steps
A mixture of 170 mg of 2-fluoro-5-nitrobenzaldehyde, 126 mg of methyl 3-aminocrotonate and 253 mg of 2-(N-benzyl-N-methylamino)ethyl acetoacetate in 1 ml of 2-propanol was reacted and then purified in the same way as in Example 9 to yield 200 mg of the desired compound (144).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04578395 |
| Source dataset | uspto-grants-1986_03 |
| ORD ID | ord-bfcc1d20813543599bc6b2b7414a02ad |
| Source note | uspto-grants-1986_03 |