HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- → 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl ethyl 2,6-dimethyl-4-(2-fluoro-3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| Reactant | 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate | HCID 10108340 | — |
| Reactant | 2-Fluoro-3-nitrobenzaldehyde | HCID 10487325 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl ethyl 2,6-dimethyl-4-(2-fluoro-3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | HCID 70040221 | 20.3% |
Reaction Steps
A mixture of 184 mg of 2-fluoro-3-nitrobenzaldehyde, 324 mg of 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate and 138 mg of ethyl 3-aminocrotonate in 1 ml of 2-propanol was reacted and then purified in the same way as in Example 8 to yield 120 mg of the desired compound (162).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04578395 |
| Source dataset | uspto-grants-1986_03 |
| ORD ID | ord-d5dc1583fb0d4c4389a89e66fc751d7a |
| Source note | uspto-grants-1986_03 |