HRID483209

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID643756

未命名化合物

HCID10108340

未命名化合物

HCID10487325

2-FLUORO-3-NITROBENZALDEHYDE

C7H4FNO3

PRODUCTS

生成物

结构：CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC(C)(C)CN(C)Cc2ccccc2)C1c1cccc([N+](=O)[O-])c1F

HCID70040221

未命名化合物

收率 20.3%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A mixture of 184 mg of 2-fluoro-3-nitrobenzaldehyde, 324 mg of 3-(N-benzyl-N-methylamino)-2,2-dimethylpropyl acetoacetate and 138 mg of ethyl 3-aminocrotonate in 1 ml of 2-propanol was reacted and then purified in the same way as in Example 8 to yield 120 mg of the desired compound (162).

WORKUP

后处理

customwas reacted
custompurified in the same way as in Example 8

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d5dc1583fb0d4c4389a89e66fc751d7a
来源数据集: uspto-grants-1986_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04578395
来源说明: uspto-grants-1986_03

反应 SMILES

[F:1][C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[C:13]([O:19][CH2:20][C:21]([CH3:33])([CH3:32])[CH2:22][N:23]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:24])(=[O:18])[CH2:14][C:15]([CH3:17])=O.[NH2:34]/[C:35](/[CH3:42])=[CH:36]\[C:37]([O:39][CH2:40][CH3:41])=[O:38]>CC(O)C>[CH3:17][C:15]1[NH:34][C:35]([CH3:42])=[C:36]([C:37]([O:39][CH2:40][CH3:41])=[O:38])[CH:4]([C:3]2[CH:6]=[CH:7][CH:8]=[C:9]([N+:10]([O-:12])=[O:11])[C:2]=2[F:1])[C:14]=1[C:13]([O:19][CH2:20][C:21]([CH3:33])([CH3:32])[CH2:22][N:23]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:24])=[O:18]