Oxalyl chloride → HCID 54425176, compound
Reaction equation
[F:1][CH:2]([CH:6]([CH3:9])[CH2:7][CH3:8])[C:3](O)=[O:4].C(Cl)(=O)C([Cl:13])=O>ClCCl>[F:1][CH:2]([CH:6]([CH3:9])[CH2:7][CH3:8])[C:3]([Cl:13])=[O:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 40 °C
Procedure
Finally, to the compound (v) was added 10 ml of dichloromethane and then 15 ml of oxalic acid chloride dropwise with ice cooling. The reaction was carried out under reflux at 40° C. for 3 hours. The reaction product was freed of chloromethane and oxalic acid chloride by atmospheric distillation, and the residues were purified by vacuum distillation. Thus there was obtained 2-fluoro-3-methylpentanoic acid chloride (vi), which has a boiling point of 58°-60° C. (at 20 mmHg).
Workup
- distillationThe reaction product was freed of chloromethane and oxalic acid chloride by atmospheric distillation
- distillationthe residues were purified by vacuum distillation
Sources & evidence
- ORD record
- ord-da6bdb019bbd4e6081af3d78a728ff6c
- Source dataset
- uspto-grants-1993_07
- Patent number
- US05225105
Reaction notes
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