Diethyl Ether → 2-Acetylamino-2-cyano-bicyclo[3.2.1]octane
Reaction equation
[NH2:1][C:2]1([C:10]#[N:11])[CH2:8][CH2:7][CH:6]2[CH2:9][CH:3]1[CH2:4][CH2:5]2.[CH2:12]([O:14]CC)[CH3:13]>C(OC(=O)C)(=O)C>[C:12]([NH:1][C:2]1([C:10]#[N:11])[CH2:8][CH2:7][CH:6]2[CH2:9][CH:3]1[CH2:4][CH2:5]2)(=[O:14])[CH3:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The procedure is as in Example 1, but starting from 2-amino-2-cyano-bicyclo[3.2.1]octane (8.05 g), in the form of the mixture of the exo and endo racemates in a ratio of (8/1), in diethyl ether (150 cc) and acetic anhydride (5.6 cc); 2-acetylamino-2-cyano-bicyclo[3.2.1]octane (10.16 g) is obtained in the form of fine white crystals which melt at 78°-80° C.
Sources & evidence
- ORD record
- ord-c50171ae0c20482ca60318b9f36f95bf
- Source dataset
- uspto-grants-1993_07
- Patent number
- US05225207
Reaction notes
Loading…