Diethyl Ether → 2-Acetylamino-2-cyano-bicyclo[3.2.1]octane

Participants

Reaction Steps

The procedure is as in Example 1, but starting from 2-amino-2-cyano-bicyclo[3.2.1]octane (8.05 g), in the form of the mixture of the exo and endo racemates in a ratio of (8/1), in diethyl ether (150 cc) and acetic anhydride (5.6 cc); 2-acetylamino-2-cyano-bicyclo[3.2.1]octane (10.16 g) is obtained in the form of fine white crystals which melt at 78°-80° C.

Provenance & Evidence