Hydrochloric Acid → HCID 19752110, compound

Participants

Reaction Steps

The procedure is as Example 1, but starting from 2-acetylamino 2-acetylaminomethyl-bicyclo[2.2.2]octane (4.6 g) in a 6N solution (100 cc) of hydrochloric acid in water for 48 hours under reflux; taking up the residue from the evaporation in ethanol (25 cc) and diethyl ether (75 cc), 2-amino-2-aminomethyl-bicyclo[2.2.2]octane dihydrochloride (3 g) is obtained in the form of white crystals which melt at 302°-303° C.

Provenance & Evidence