Hydrochloric Acid → HCID 19752110, compound

HRID 483319Notes

Reaction equation

HRID 483319 reaction equation
C([NH:4][C:5]1([CH2:13][NH:14]C(=O)C)[CH2:10][CH:9]2[CH2:11][CH2:12][CH:6]1[CH2:7][CH2:8]2)(=O)C.[ClH:18]>O>[ClH:18].[ClH:18].[NH2:4][C:5]1([CH2:13][NH2:14])[CH2:10][CH:9]2[CH2:11][CH2:12][CH:6]1[CH2:7][CH2:8]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19752084HCID 19752084, compound

Product 1

HCID 19752110HCID 19752110, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The procedure is as Example 1, but starting from 2-acetylamino 2-acetylaminomethyl-bicyclo[2.2.2]octane (4.6 g) in a 6N solution (100 cc) of hydrochloric acid in water for 48 hours under reflux; taking up the residue from the evaporation in ethanol (25 cc) and diethyl ether (75 cc), 2-amino-2-aminomethyl-bicyclo[2.2.2]octane dihydrochloride (3 g) is obtained in the form of white crystals which melt at 302°-303° C.

Workup

  1. temperatureunder reflux
  2. customfrom the evaporation in ethanol (25 cc)

Sources & evidence

ORD record
ord-86a81c5f81af4fc0b3102e70d3c3e290
Source dataset
uspto-grants-1993_07
Patent number
US05225207

Reaction notes

Loading…