Hydrochloric Acid → HCID 19752108, compound

Participants

Reaction Steps

The procedure is as in Example 3, but starting from 2-acetylamino-2-acetylaminomethyl-bicyclo[2.2.1]heptane (7.85 g), in the form of the exo racemate, in a 6N solution (250 cc) of hydrochloric acid in water for 8 hours under reflux; taking up the residue from the evaporation in ethanol (100 cc) and diethyl ether (300 cc), 2-amino-2-aminomethyl-bicyclo[2.2.1]heptane dihydrochloride (6.87 g) is obtained in the form of white crystals which melt at 271° C.

Provenance & Evidence