Hydrochloric Acid → HCID 19752108, compound

HRID 483322Notes

Reaction equation

HRID 483322 reaction equation
C([NH:4][C:5]1([CH2:12][NH:13]C(=O)C)[CH2:10][CH:9]2[CH2:11][CH:6]1[CH2:7][CH2:8]2)(=O)C.[ClH:17]>O>[ClH:17].[ClH:17].[NH2:4][C:5]1([CH2:12][NH2:13])[CH2:10][CH:9]2[CH2:11][CH:6]1[CH2:7][CH2:8]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19752088HCID 19752088, compound

Product 1

HCID 19752108HCID 19752108, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The procedure is as in Example 3, but starting from 2-acetylamino-2-acetylaminomethyl-bicyclo[2.2.1]heptane (7.85 g), in the form of the exo racemate, in a 6N solution (250 cc) of hydrochloric acid in water for 8 hours under reflux; taking up the residue from the evaporation in ethanol (100 cc) and diethyl ether (300 cc), 2-amino-2-aminomethyl-bicyclo[2.2.1]heptane dihydrochloride (6.87 g) is obtained in the form of white crystals which melt at 271° C.

Workup

  1. temperatureunder reflux
  2. customfrom the evaporation in ethanol (100 cc)

Sources & evidence

ORD record
ord-8d899ea970d7449c843302f9f2f02c11
Source dataset
uspto-grants-1993_07
Patent number
US05225207

Reaction notes

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