Bromine → HCID 10085313, compound

HRID 483339Notes

Reaction equation

HRID 483339 reaction equation
[C:1]1([CH3:15])[CH:6]=[CH:5][C:4]([C:7](=[O:14])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][CH:2]=1.[Br:16]Br>C(Cl)(Cl)(Cl)Cl>[Br:16][CH:8]([C:7]([C:4]1[CH:3]=[CH:2][C:1]([CH3:15])=[CH:6][CH:5]=1)=[O:14])[C:9]([O:11][CH2:12][CH3:13])=[O:10]

Participants

4

Reactant 2

HCID 24408BromineHCID 292637Ethyl 3-(4-methylphenyl)-3-oxopropanoate

Product 1

HCID 10085313HCID 10085313, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent2×

Conditions

Temperature
20 °C

Procedure

20.4 g of ethyl 3-p-tolyl-3-oxopropionate (Helv. Chim. Acta 57, 2205 (1974)) are dissolved in 20 ml of CCl4. A solution of 6 ml of bromine in 30 ml of CCl4 is added dropwise at -5° C. After 1 hour at -5° C., the mixture is stirred at 20° C. for 3 h and then at 60° C. for 1 h. the solvent is removed. The title compound is used further as crude product; yield 34 g.

Workup

  1. customat 60° C. for 1 h. the solvent is removed

Sources & evidence

ORD record
ord-69d0f6b394674a0c8e08738451e76b3c
Source dataset
uspto-grants-1993_07
Patent number
US05225414

Reaction notes

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