Hydrochloric Acid → HCID 11075076, compound

HRID 483376Notes

Reaction equation

HRID 483376 reaction equation
[OH:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4].Cl.[CH3:17]O>>[OH:1][CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)[C:3]([O:5][CH3:17])=[O:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 15272405HCID 15272405, compound

Product 1

HCID 11075076HCID 11075076, compound

Procedure

A solution of the product from step (a) (3.0 g) and c.HCl (0.5 ml) in methanol (100 ml) was refluxed for 1 hour. The solvents were evaporated in vacuo and the residue flash chromatographed through a silica column using methanol/chloroform (3:100 v/v) to give the desired product as a pale yellow solid (2.7 g). The 200 MHz 1H NMR was consistent with the proposed structure.

Workup

  1. customThe solvents were evaporated in vacuo
  2. customthe residue flash chromatographed through a silica column

Sources & evidence

ORD record
ord-e5128bccb8bd4e45887b526513645d0c
Source dataset
uspto-grants-1993_07
Patent number
US05225431

Reaction notes

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