Ammonia → 2-(7-Methoxynaphthalen-1-yl)acetamide

HRID 483392Notes

Reaction equation

HRID 483392 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14](Cl)=[O:15])=[CH:5][CH:4]=1.[NH3:17]>CCOCC>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14]([NH2:17])=[O:15])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 193857662-(7-Methoxynaphthalen-1-yl)acetyl chloride

Product 1

HCID 151491272-(7-Methoxynaphthalen-1-yl)acetamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

The (7-methoxynaphth-1-yl)acetyl chloride obtained above is dissolved in 200 ml of anhydrous ether. After cooling the solution in an ice/salt bath, 200 ml of concentrated aqueous ammonia solution are added with agitation. The mixture is agitated for 30 minutes and the precipitate formed is spun down and recrystallized in ethanol.

Workup

  1. temperatureAfter cooling the solution in an ice/salt bath
  2. customthe precipitate formed
  3. customrecrystallized in ethanol

Sources & evidence

ORD record
ord-164ba8c86b26412083727fb95a2d5568
Source dataset
uspto-grants-1993_07
Patent number
US05225442

Reaction notes

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