Triethylamine → 2-(7-Methoxynaphthalen-1-yl)acetonitrile

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Reaction Steps

The (7-methoxynaphth-1-yl)acetamide obtained in Stage E is suspended in 80 ml of anhydrous THF, and triethylamine is added. The solution is cooled in an ice bath, and then trifluoroacetic anhydride is added dropwise with magnetic agitation. Agitation is continued for one hour at room temperature. Then the mixture is dried and the residue taken up in water. The precipitate which forms is spun down, dried and recrystallized in isopropyl ether.

Provenance & Evidence