Triethylamine → 2-(7-Methoxynaphthalen-1-yl)acetonitrile

HRID 483393Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 483393
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14]([NH2:16])=O)=[CH:5][CH:4]=1.C(N(CC)CC)C.FC(F)(F)C(OC(=O)C(F)(F)F)=O>C1COCC1>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][CH:9]=[C:10]2[CH2:13][C:14]#[N:16])=[CH:5][CH:4]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 9845Trifluoroacetic anhydrideHCID 151491272-(7-Methoxynaphthalen-1-yl)acetamide

Produkt 1

HCID 112640682-(7-Methoxynaphthalen-1-yl)acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

The (7-methoxynaphth-1-yl)acetamide obtained in Stage E is suspended in 80 ml of anhydrous THF, and triethylamine is added. The solution is cooled in an ice bath, and then trifluoroacetic anhydride is added dropwise with magnetic agitation. Agitation is continued for one hour at room temperature. Then the mixture is dried and the residue taken up in water. The precipitate which forms is spun down, dried and recrystallized in isopropyl ether.

Aufarbeitung

  1. temperatureThe solution is cooled in an ice bath
  2. customThen the mixture is dried
  3. customdried
  4. customrecrystallized in isopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-0d8297132e0147d980039df82d6e1541
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05225442

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