Potassium Carbonate → HCID 178487441, compound

HRID 483399Notes

Reaction equation

HRID 483399 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][CH:10]=[C:11]2[CH2:14][CH2:15][NH2:16])=[CH:6][CH:5]=1.C(=O)([O-])[O-].[K+].[K+].Cl.[NH:24]1[CH:28]=[C:27]([CH2:29][C:30](Cl)=[O:31])[N:26]=[CH:25]1>C(Cl)(Cl)Cl.O>[CH3:2][O:3][C:4]1[CH:13]=[C:12]2[C:7]([CH:8]=[CH:9][CH:10]=[C:11]2[CH2:14][CH2:15][NH:16][C:30](=[O:31])[CH2:29][C:27]2[N:26]=[CH:25][NH:24][CH:28]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 160500552-(7-Methoxynaphthalen-1-yl)ethan-1-amine hydrochlorideHCID 178479698HCID 178479698, compound

Product 1

HCID 178487441HCID 178487441, compound

Reagents, catalysts & solvents 1

HCID 22418719Chloroform waterSolvent

Procedure

0.01 mol of 2-(7-methoxynaphth-1-yl)ethylamine hydrochloride is dissolved in 60 ml of a chloroform/water mixture, and 0.025 mol of potassium carbonate is added under magnetic agitation. The mixture is cooled, and 0.012 mol of 4-imidazoleacetyl chloride hydrochloride is added dropwise. The agitation is maintained for 30 minutes at room temperature and the chloroform phase is evaporated to dryness. The residue is then recrystallized.

Workup

  1. temperatureThe mixture is cooled
  2. customthe chloroform phase is evaporated to dryness
  3. customThe residue is then recrystallized

Sources & evidence

ORD record
ord-8fde4bc79aec4bcf995c8d7a6e57bb82
Source dataset
uspto-grants-1993_07
Patent number
US05225442

Reaction notes

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