HCID 15035365, compound → HCID 15035366, compound

HRID 483408Notes

Reaction equation

HRID 483408 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([F:16])=[CH:13][CH:14]=3)[C:9]([S:17][CH3:18])=[C:8]2[CH2:19][C:20]([O:22]CC)=[O:21])=[CH:4][CH:3]=1>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([F:16])=[CH:13][CH:14]=3)[C:9]([S:17][CH3:18])=[C:8]2[CH2:19][C:20]([OH:22])=[O:21])=[CH:25][CH:26]=1

Participants

3

Reactant 1

HCID 15035365HCID 15035365, compound

Product 1

HCID 15035366HCID 15035366, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the procedure of Preparation 6, but using ethyl 1-(p-chlorobenzyl)-5-fluoro-3-methylthioindole-2-acetate from Example 3 as the starting material and tetrahydrofuran as the solvent, the title compound was prepared, mp 154 155° C. (dec.).

Workup

  1. customthe procedure of Preparation 6

Sources & evidence

ORD record
ord-be8d8245347947f1b96abab4125e3e13
Source dataset
uspto-grants-1993_07
Patent number
US05225421

Reaction notes

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