Tetrahydrofuran → HCID 53727394, compound

HRID 483411Notes

Reaction equation

HRID 483411 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([F:16])=[CH:13][CH:14]=3)[C:9]([S:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[C:8]2[CH2:24][C:25]([O:27]CC)=[O:26])=[CH:4][CH:3]=1.O1CCC[CH2:33]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([F:16])=[CH:13][CH:14]=3)[C:9]([S:17][C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=3)=[C:8]2[CH:24]([CH3:33])[C:25]([OH:27])=[O:26])=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 15035370HCID 15035370, compound

Product 1

HCID 53727394HCID 53727394, compound

Procedure

Following the procedure of Example 6, but using ethyl 1-(p-chlorobenzyl)-5-fluoro-3-phenylthioindole-2-acetate (Example 8, Step 1) as the starting material and tetrahydrofuran as the solvent, the title compound was prepared, mp 80°-82°.

Sources & evidence

ORD record
ord-217aa82a954544b2b35679aeca42049a
Source dataset
uspto-grants-1993_07
Patent number
US05225421

Reaction notes

Loading…