Hydrochloric Acid → HCID 19030802, compound

HRID 483522Notes

Reaction equation

HRID 483522 reaction equation
[C:1]([C:3]1[CH:27]=[CH:26][C:6]([C:7]([N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19][CH2:18][C:16]3=[O:17])[CH2:11][CH2:10]2)=[O:8])=[CH:5][CH:4]=1)#[N:2].[CH2:28]([OH:30])[CH3:29].Cl>C(Cl)(Cl)Cl>[CH2:28]([O:30][C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:9]2[CH2:10][CH2:11][CH:12]([N:15]3[C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[CH2:19][CH2:18][C:16]3=[O:17])[CH2:13][CH2:14]2)=[O:8])=[CH:26][CH:27]=1)=[NH:2])[CH3:29]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14969532HCID 14969532, compound

Product 1

HCID 19030802HCID 19030802, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1-[1-(4-Cyanobenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril (1 g) is dissolved in chloroform (10 ml) and thereto is added ethanol (0.18 ml). Under ice cooling, hydrochloric acid gas is passed through the mixture to saturate and further the mixture is stirred at 5°-7° C. for 4 days. After the reaction, the solvent is concentrated to give 1-{1-[4-(1-ethoxy-1-iminomethyl)benzoyl]-4-piperidinyl}-3,4-dihydrocarbostyril (1 g). This product is used for the subsequent reaction.

Workup

  1. concentrationto saturate
  2. customAfter the reaction
  3. concentrationthe solvent is concentrated

Sources & evidence

ORD record
ord-e02c00ea12f14839b3c393fb51e897ca
Source dataset
uspto-grants-1993_07
Patent number
US05225402

Reaction notes

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