反应详情

1-[1-(4-Formylbenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril (4.77 g) is dissolved in methanol (100 ml) and thereto is added carbomethoxymethylenetriphenylphosphorane (5.3 g) and the mixture is stirred at room temperature for 1 hour. The solvent is concentrated and the residue is purified roughly by silica gel column chromatography (solvent: n-hexane:ethyl acetate=1:1) to give a mixture (8 g) of 1-{1-[4-(2-methoxycarbonylvinyl)benzoyl]-4-piperidinyl]-3,4-dihydrocarbostyril and triphenylphosphineoxide.

1. concentrationThe solvent is concentrated
2. customthe residue is purified roughly by silica gel column chromatography (solvent: n-hexane:ethyl acetate=1:1)