反应详情

A solution of 10.13 g of ethyl 3-amino-benzoate and 6.82 g of triethylamine in 100 ml of methylene chloride is added dropwise to a solution of p-tetradecyloxyphenylacetyl chloride in 100 ml of methylene chloride over 15 minutes. The mixture is stirred for an additional 2.5 hours then washed with dilute hydrochloric acid. The organic layer is evaporated and the residue dissolved in 1.5 liter of ether then washed with dilute sodium hydroxide. The organic layer is dried and evaporated to a residue which is crystallized from carbon tetrachloride:hexane to give 24.4 g of the desired product as a white solid, m.p. 91°-94° C.

1. washthen washed with dilute hydrochloric acid
2. customThe organic layer is evaporated
3. dissolutionthe residue dissolved in 1.5 liter of ether
4. washthen washed with dilute sodium hydroxide
5. customThe organic layer is dried
6. customevaporated to a residue which
7. customis crystallized from carbon tetrachloride