Hydrochloric Acid → HCID 69892350, compound

HRID 48356Notes

Reaction equation

HRID 48356 reaction equation
[ClH:1].C([CH:6]([NH:12][C:13](=[O:34])[C:14]1[CH:19]=[CH:18][C:17](/[CH:20]=[CH:21]/[C:22]2[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[N:26]([CH3:33])[CH2:25][CH2:24][N:23]=2)=[CH:16][CH:15]=1)[CH2:7][NH:8]C(=O)[O-])(C)(C)C>C(OCC)C>[ClH:1].[NH2:8][CH2:7][CH2:6][NH:12][C:13](=[O:34])[C:14]1[CH:15]=[CH:16][C:17]([CH:20]=[CH:21][C:22]2[C:28]3[CH:29]=[CH:30][CH:31]=[CH:32][C:27]=3[N:26]([CH3:33])[CH2:25][CH2:24][N:23]=2)=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86585820(tert-butyl (E)-[2-[4-[2-(2,3-dihydro-1-methyl-1H-1,4-benzodiazepin-5-yl)-vinyl]-benzamido]ethyl)]carbamate

Product 1

HCID 69892350HCID 69892350, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A few drops of a saturated solution of hydrogen chloride in diethyl ether were added to a solution of 15 mg (0.033 mmol) (tert-butyl (E)-[2-[4-[2-(2,3-dihydro-1-methyl-1H-1,4-benzodiazepin-5-yl)-vinyl]-benzamido]ethyl)]carbamate. The mixture was stirred at room temperature for 16 hours and the resultant solid filtered off, dissolved in methanol and evaporated. There was obtained 8 mg of N-(2-aminoethyl)-4-[2-(2,3-dihydro-1-methyl-1H-1,4-benzodiazepin-5-yl)vinyl]benzamide hydrochloride as a dark red gum MS: m/e 349.0 [M+H]+.

Workup

  1. filtrationthe resultant solid filtered off
  2. dissolutiondissolved in methanol
  3. customevaporated

Sources & evidence

ORD record
ord-5c0842ef7f70468d911fa0f8232754d8
Source dataset
uspto-grants-2004_03
Patent number
US06703387B2

Reaction notes

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