反应详情

A mixture of 54.0 g of 2-methyl-1-(p-nitrophenyl)imidazole, 2.87 g of palladium black, 36.7 g of sodium formate and 47.4 ml of formic acid in 1100 ml of methyl alcohol is stirred at room temperature for 18 hours under a hydrogen atmosphere. The mixture is filtered and the filtrate evaporated to a residue. The residue is partitioned between saturated potassium bicarbonate and chloroform. The organic layer is dried and passed through a pad of hydrous magnesium silicate. The filtrate is evaporated to a residue which is crystallized from ether:ethanol to give 34.9 g of the desired product as a solid, m.p. 108°-110° C.

1. filtrationThe mixture is filtered
2. customthe filtrate evaporated to a residue
3. customThe residue is partitioned between saturated potassium bicarbonate and chloroform
4. customThe organic layer is dried
5. customThe filtrate is evaporated to a residue which
6. customis crystallized from ether