HCID 19753204, Verbindung → 8-Amino-6-methoxy-2-methoxycarbonylchromone

HRID 483602Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 483602
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([N+:13]([O-])=O)[CH:12]=1)[O:9][C:8]([C:16]([O:18][CH3:19])=[O:17])=[CH:7][C:6]2=[O:20]>C(O)(=O)C.[C].[Pd]>[NH2:13][C:11]1[CH:12]=[C:3]([O:2][CH3:1])[CH:4]=[C:5]2[C:10]=1[O:9][C:8]([C:16]([O:18][CH3:19])=[O:17])=[CH:7][C:6]2=[O:20]

Komponenten

4

Edukt 1

HCID 19753204HCID 19753204, Verbindung

Produkt 1

HCID 197532018-Amino-6-methoxy-2-methoxycarbonylchromoneAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

In 50 ml of acetic acid was dissolved 2.98 g (10.67 mmol) of 6-methoxy-2-methoxycarbonyl-8-nitrochromone, and the mixture was stirred at room temperature for 1.5 hour in the presence of 1.0 g of 5% palladium carbon while bubbling hydrogen gas thereinto. After completion of the reaction, the inorganic substance was filtered off, and the filtrate was concentrated under reduced pressure. The residue was dissolved in 100 ml of chloroform, and washed with an aqueous saturated sodium hydrogen carbonate solution. The organic layer was concentrated under reduced pressure to obtain 2.31 g (yield: 87%) of 8-amino-6-methoxy-2-methoxycarbonylchromone as brown crystals.

Aufarbeitung

  1. customwhile bubbling hydrogen gas
  2. customAfter completion of the reaction
  3. filtrationthe inorganic substance was filtered off
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. dissolutionThe residue was dissolved in 100 ml of chloroform
  6. washwashed with an aqueous saturated sodium hydrogen carbonate solution
  7. concentrationThe organic layer was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-30f36dc978dc4a319e597cfff0b5a37f
Quelldatensatz
uspto-grants-1993_07
Patentnummer
US05225559

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