Hydrochloric Acid → 1-Cyclopentyl-ethylamine * HCl

HRID 483670Notes

Reaction equation

HRID 483670 reaction equation
[CH:1]1([CH:6]([NH2:8])[CH3:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:9].[OH-].[Na+]>O>[ClH:9].[CH:1]1([CH:6]([NH2:8])[CH3:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10996991(1-cyclopentylethyl)amine(SALTDATA: HCl)

Product 1

HCID 197534611-Cyclopentyl-ethylamine * HCl

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The 1-cyclopentylethyl amine (S/R=3/1) was converted to the hydrochloride by dissolving the combined product of 3 runs (12.4 g) in 200 ml H2O, adjusting the pH to 12.0 with solid NaOH pellets and extracting three times with 100 ml diethyl ether. The combined ether extracts were dried over Na2SO4, then treated with a solution of 2 g HCl in 100 ml methanol (with cooling) and this solution was evaporated to give 1-cyclopentylethyl amine hydrochloride as a white solid - 8.46 g, mp 192- 4° C.

Workup

  1. extractionextracting three times with 100 ml diethyl ether
  2. dry with materialThe combined ether extracts were dried over Na2SO4
  3. additiontreated with a solution of 2 g HCl in 100 ml methanol (with cooling)
  4. customthis solution was evaporated

Sources & evidence

ORD record
ord-566c8ea7f1cc4954b7901b3778306972
Source dataset
uspto-grants-1993_07
Patent number
US05225591

Reaction notes

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