HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Tetrahydrofuran → 3-[4-(Aminomethyl)-3-fluorophenyl]propylamine dihydrochlorde
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Tetrahydrofuran | HCID 8028 | — |
| Edukt | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Edukt | Boron, trihydro(thiobis(methane))-, (T-4)- | HCID 9833925 | — |
| Edukt | 4-(3-Aminopropyl)-2-fluorobenzenecarbonitrile | HCID 22743242 | — |
| Produkt | 3-[4-(Aminomethyl)-3-fluorophenyl]propylamine dihydrochlorde | HCID 22743258 | 73% |
Reaktionsschritte
Scheme IIIb, step C: 4-(3-Aminopropyl)-2-fluorobenzenecarbonitrile (1.1 g, 6.17 mmol) and boron dimethylsulfide 2M in THF (6.2 mL, 12.34 mmol) were combined and reduction was carried out in a manner analogous to the procedure described in example 6 to provide the intermediate title compound, 3-[4-(aminomethyl)-3-fluorophenyl]propylamine dihydrochlorde, (1.15 g, 73%) as a dihydrochloride salt. Electron spray M.S. 183 (M*+H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06703425B2 |
| Quelldatensatz | uspto-grants-2004_03 |
| ORD ID | ord-0b9e30f3f7794c1395bfc3dca421aae1 |
| Quellennotiz | uspto-grants-2004_03 |