Hydrochloric Acid → HCID 14850584, compound

HRID 483718Notes

Reaction equation

HRID 483718 reaction equation
[C:1]([C:5]1[CH:26]=[CH:25][C:8]([CH2:9][NH:10][C:11]2[CH:20]=[CH:19][C:18]3[C:17]([CH3:22])([CH3:21])[CH2:16][CH2:15][C:14]([CH3:24])([CH3:23])[C:13]=3[CH:12]=2)=[CH:7][CH:6]=1)([O:3]C)=[O:2].[OH-].[K+].Cl>C(O)C.CS(C)=O.O>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([CH2:9][NH:10][C:11]2[CH:20]=[CH:19][C:18]3[C:17]([CH3:21])([CH3:22])[CH2:16][CH2:15][C:14]([CH3:24])([CH3:23])[C:13]=3[CH:12]=2)=[CH:25][CH:26]=1)([OH:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 10315958HCID 10315958, compound

Product 1

HCID 14850584HCID 14850584, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 86745966HCID 86745966, compoundSolvent

Procedure

2 g of this ester and 2.5 g of potassium hydroxide in 45 ml of 5:1:3 ethanol/dimethyl sulfoxide/water were refluxed for 1 hour. At room temperature, 20 ml of 2N hydrochloric acid were added to the solution. The precipitate was filtered off, recrystallized from methanol and yielded 1.1 g of the title compound of melting point 225°-231° C.

Workup

  1. filtrationThe precipitate was filtered off
  2. customrecrystallized from methanol

Sources & evidence

ORD record
ord-34bc9533d8e54788aef55124ce131034
Source dataset
uspto-grants-1993_07
Patent number
US05225601

Reaction notes

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