反应详情

Scheme Vc, step A: 2-(4-Iodophenyl) propyl isopropylsulfonamide (1.5 g, 4.1 mmol), (phenylmethoxy)-N-prop-2-enylcarboxamide (0.94 g, 4.9 mmol, prepared in example 8), 9-BBN dimer (0.8 g, 3.28 mmol), [1,1′bis(diphenylphosphino)-ferrocene] dichloropalladium (II), PdCl2(dppf) (0.17 g, 0.2 mmol), 3N sodium hydroxide (3 mL), and pH=7 buffer: hydrogen peroxide (2:1, 15 mL) were combined in a manner analogous to the procedure described in example 6 to provide the intermediate title compound, N-{3-[4-(1-methyl-2-{[(methylethyl)sulfonyl]amino}ethyl)phenyl]propyl}(phenylmethoxy)carboxamide, (1.74 g, 99%). Electron spray M.S. 431 (M*−H).