反应详情

2-Chloro-4-methoxypyridine-1-oxide (3.3 g) is dissolved in 10% w/v aqueous NaOH (33 ml) and the mixture is heated on a steam bath for 3.5 hours when it is cooled and acidified with concentrated HCl to a pH of 2.5 to yield white crystals. Recrystallisation of these from water gives 1-hydroxy-4-methoxypyrid-2-one (0.75 g, 20%), m.p. 174°-175° C., δ(D2O) 5.9 (s, 1H), 6.00 (q, 1H), 7.5 (d, 1H).

1. temperaturethe mixture is heated on a steam bath for 3.5 hours when it
2. temperatureis cooled
3. customto yield white crystals
4. customRecrystallisation of these from water