Potassium Hydroxide → HCID 15157668, compound

HRID 483778Notes

Reaction equation

HRID 483778 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([O:13][CH3:14])=[CH:10][CH:11]=2)[C:6]([CH:15]2[CH:20]3[CH2:21][CH2:22][N:17]([CH2:18][CH2:19]3)[CH2:16]2)=[C:5]1[CH3:23])(=O)C.[OH-].[K+]>O.C(O)C>[CH3:14][O:13][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][CH:10]=1)[NH:4][C:5]([CH3:23])=[C:6]2[CH:15]1[CH:20]2[CH2:19][CH2:18][N:17]([CH2:22][CH2:21]2)[CH2:16]1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 15157721HCID 15157721, compound

Product 1

HCID 15157668HCID 15157668, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

200 mg of 3-(1-Acetyl-5-methoxy-2-methyl-3-indolyl)quinuclidine are stirred on a steam bath for 16 hours with 100 mg of KOH in 7 ml of water and 14 ml of ethanol. The mixture is then worked up as is customary. 3-(5-methoxy-2-methyl-3-indolyl)quinuclidine is obtained; hydrochloride, m.p. 231.7°-234.0°.

Sources & evidence

ORD record
ord-73f030f0a7434dd6bbc4516a39e4830f
Source dataset
uspto-grants-1993_07
Patent number
US05227386

Reaction notes

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