HCID 19103244, compound → HCID 19103208, compound

HRID 483821Notes

Reaction equation

HRID 483821 reaction equation
C[O:2][CH:3](OC)[C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:6][C:5]=1[C:18](=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CC(C)=O.Cl.CCOCC>[C:18]([C:5]1[CH:6]=[CH:7][C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:9][C:4]=1[CH:3]=[O:2])(=[O:25])[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

5

Reactant 1

HCID 19103244HCID 19103244, compound

Product 1

HCID 19103208HCID 19103208, compound

Reagents, catalysts & solvents 3

HCID 180AcetoneSolventHCID 313Hydrochloric AcidSolventHCID 3283Diethyl EtherSolvent

Procedure

A solution of crude ketone from Step 1 in acetone (250 mL) and HCl 10% (25 mL) was stirred for 6 hours, diluted with Et2O, washed with a saturated NH4Cl solution, H2O (3×), brine and dried (MgSO4). After evaporation of the solvent, the residue was saturated with hexane and filtered to afford the title compound as pale yellow solid.

Workup

  1. washwashed with a saturated NH4Cl solution, H2O (3×), brine
  2. dry with materialdried (MgSO4)
  3. customAfter evaporation of the solvent
  4. filtrationfiltered

Sources & evidence

ORD record
ord-bcc813ab116c4bf28005dc258ff8cbe6
Source dataset
uspto-grants-1993_07
Patent number
US05227399

Reaction notes

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