Pyridine → HCID 10842123, compound

HRID 483824Notes

Reaction equation

HRID 483824 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)=[C:14]([CH:38]([OH:40])[CH3:39])[C:15]([CH2:19][O:20][Si:21]([C:34]([CH3:37])([CH3:36])[CH3:35])([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:16]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.[CH3:53][C:54](OC(C)=O)=[O:55]>CN(C1C=CN=CC=1)C.CCOCC>[C:54]([O:40][CH:38]([C:14]1[C:15]([CH2:19][O:20][Si:21]([C:34]([CH3:37])([CH3:36])[CH3:35])([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)=[CH:16][C:17]2[C:12]([C:13]=1[C:41]1[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=1)=[CH:11][CH:10]=[C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH:18]=2)[CH3:39])(=[O:55])[CH3:53]

Participants

6

Reactant 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 10817689HCID 10817689, compound

Product 1

HCID 10842123HCID 10842123, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 3283Diethyl EtherSolvent

Procedure

To a solution alcohol (300 mg) from Step 4 in Ac2O (2 mL) was added pyridine (300 mL) and DMAP (2 mg). After 2 hr, the reaction mixture was diluted with Et2O, washed with H2O, a solution of CuSO4, and the solvent evaporated to give the title product which was used as such for the next step.

Workup

  1. washwashed with H2O
  2. customa solution of CuSO4, and the solvent evaporated

Sources & evidence

ORD record
ord-3890f15c06c04a08a28f96a559be1b87
Source dataset
uspto-grants-1993_07
Patent number
US05227399

Reaction notes

Loading…