反应详情

To 50 ml of distilled tetrahydrofuran were added 3.2 g of 1-methyl-3-cyclooctylmethylaminocarbonylpiperidine and 1.5 g of lithium aluminum hydride. The mixture was refluxed for 10 hours under a nitrogen current. After cooling, the reaction mixture was mixed with methanol and 2N sodium hydroxide. The resulting mixture was stirred and then the insoluble materials were removed by filtration. The filtrate was concentrated. The residue was distilled in a glass tube over under reduced pressure to obtain 2.6 g of N-(1-methyl-3-piperidinylmethyl)-N-cyclooctylmethylamine.

1. temperatureThe mixture was refluxed for 10 hours under a nitrogen current
2. temperatureAfter cooling
3. customthe insoluble materials were removed by filtration
4. concentrationThe filtrate was concentrated
5. distillationThe residue was distilled in a glass tube over under reduced pressure