HCID 10016034, compound → HCID 135518082, compound

HRID 483853Notes

Reaction equation

HRID 483853 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:10][C:11]3[CH:17]=[C:16]([O:18]C)[CH:15]=[CH:14][C:12]=3[N:13]=2)=[CH:5][CH:4]=1>C(O)(=O)C.Br>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:10][C:11]3[CH:17]=[C:16]([OH:18])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 10016034HCID 10016034, compound

Product 1

HCID 135518082HCID 135518082, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 260Hydrogen BromideSolvent

Procedure

20 g of 2-(p-methoxyphenyl)-6-methoxybenzothiazole are refluxed in a mixture of 100 ml of glacial acetic acid and 200 ml of concentrated aqueous HBr with stirring. After 14 hours the mixture is cooled down to room temperature and filtered with suction, and the filter residue is washed with water and recrystallized from ethanol. The yield is 17.2 g (95% of theory); melting point: 284°-286° C.

Workup

  1. filtrationfiltered with suction
  2. washthe filter residue is washed with water
  3. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-5962cfd8d2054648baac5df351a9d200
Source dataset
uspto-grants-1993_07
Patent number
US05227454

Reaction notes

Loading…