n-[2-(1-Methyl-5-{2-[(phenylmethoxy)carbonylamino]ethyl}benzimidazol-2-yl)ethyl](phenylmethoxy)carboxamide → HCID 12991239, compound

HRID 48391Notes

Reaction equation

HRID 48391 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([CH2:11][CH2:12][NH:13]C(OCC3C=CC=CC=3)=O)=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:24][CH2:25][NH:26]C(OCC1C=CC=CC=1)=O>[Pd]>[NH2:13][CH2:12][CH2:11][C:9]1[CH:8]=[CH:7][C:6]2[N:2]([CH3:1])[C:3]([CH2:24][CH2:25][NH2:26])=[N:4][C:5]=2[CH:10]=1

Participants

3

Reactant 1

HCID 12991238n-[2-(1-Methyl-5-{2-[(phenylmethoxy)carbonylamino]ethyl}benzimidazol-2-yl)ethyl](phenylmethoxy)carboxamide

Product 1

HCID 12991239HCID 12991239, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

N-[2-(1-Methyl-5-{2-[(phenylmethoxy)carbonylamino]ethyl}benzimidazol-2-yl)ethyl](phenylmethoxy)carboxamide (3.6 mmol) and 10% palladium on carbon (1.0 g, 62 mole %) were combined and hydrogenation was carried out in a manner analogous to the procedure described in example 6 to provide the intermediate title compound, 2-[5-(2-aminoethyl)-1-methylbenzimidazol-2-yl]ethylamine, (55%) as a colorless oil.

Sources & evidence

ORD record
ord-4dcd7b15a71b4485ad8cfeb7d00dfc15
Source dataset
uspto-grants-2004_03
Patent number
US06703425B2

Reaction notes

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