Potassium Carbonate → 1-(1H-Benzimidazol-2-yl)-4-piperidinemethanamine

HRID 484057Notes

Reaction equation

HRID 484057 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].Cl[C:16]1[NH:17][C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1>C1(C)C=CC=CC=1>[N:17]1[C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[NH:20][C:16]=1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][NH2:1])[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 235274-(Aminomethyl)piperidineHCID 785722-Chlorobenzimidazole

Product 1

HCID 197495451-(1H-Benzimidazol-2-yl)-4-piperidinemethanamine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

45 g of 4-aminomethylpiperidine are placed 500 ml of anhydrous toluene in the presence of 55 g of potassium carbonate and of 50 g of 2-chlorobenzimidazole. The mixture is subjected to reflux overnight. Aver evaporation and crystallization of the oily residue, the expected product is obtained after washing with dichloromethane.

Workup

  1. temperatureto reflux overnight
  2. customAver evaporation and crystallization of the oily residue

Sources & evidence

ORD record
ord-4657c9f99e1c4e2ea18372ccbc0a787b
Source dataset
uspto-grants-1993_07
Patent number
US05229398

Reaction notes

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