Potassium Carbonate → HCID 19749569, compound

HRID 484058Notes

Reaction equation

HRID 484058 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].[CH3:15][N:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1Cl>C1(C)C=CC=CC=1>[CH3:15][N:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][NH2:1])[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 235274-(Aminomethyl)piperidineHCID 6630802-chloro-1-methyl-1H-1,3-benzodiazole

Product 1

HCID 19749569HCID 19749569, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

27 g of 4-aminomethylpiperidine are placed in 300 ml of anhydrous toluene in the presence of 33 g of potassium carbonate and of 33 g of 1-methyl-2-chlorobenzimidazole. The mixture is subjected to reflux for 48 hours. After evaporation, the residue is taken up in ether and an excess of hydrochloric ether. The precipitate formed is spun down, washed with ether, and then taken up in 750 ml of water and 30% caustic soda is added to give a basic pH.

Workup

  1. temperatureto reflux for 48 hours
  2. customAfter evaporation
  3. customThe precipitate formed
  4. washwashed with ether
  5. addition30% caustic soda is added
  6. customto give a basic pH

Sources & evidence

ORD record
ord-a4ebb7fcb4504374b4756bcfc5682cea
Source dataset
uspto-grants-1993_07
Patent number
US05229398

Reaction notes

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