HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-(1H-Benzimidazol-2-yl)-4-piperidinemethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Aminomethyl)piperidine | HCID 23527 | — |
| Reactant | 2-Chlorobenzimidazole | HCID 78572 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-(1H-Benzimidazol-2-yl)-4-piperidinemethanamine | HCID 19749545 | — |
Reaction Steps
45 g of 4-aminomethylpiperidine are placed in 500 ml of anhydrous toluene in the presence of 55 g of potassium carbonate and of 50 g of 2-chlorobenzimidazole. The mixture is subjected to reflux overnight. Aver evaporation and crystallization of the oily residue, the expected product is obtained after washing with dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05229399 |
| Source dataset | uspto-grants-1993_07 |
| ORD ID | ord-be580a30a9b34f9bbed5e1bf558fbc35 |
| Source note | uspto-grants-1993_07 |