Potassium Carbonate → 1-(1H-Benzimidazol-2-yl)-4-piperidinemethanamine

HRID 484061Notes

Reaction equation

HRID 484061 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].Cl[C:16]1[NH:17][C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1>C1(C)C=CC=CC=1>[N:17]1[C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[NH:20][C:16]=1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][NH2:1])[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 235274-(Aminomethyl)piperidineHCID 785722-Chlorobenzimidazole

Product 1

HCID 197495451-(1H-Benzimidazol-2-yl)-4-piperidinemethanamine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

45 g of 4-aminomethylpiperidine are placed in 500 ml of anhydrous toluene in the presence of 55 g of potassium carbonate and of 50 g of 2-chlorobenzimidazole. The mixture is subjected to reflux overnight. Aver evaporation and crystallization of the oily residue, the expected product is obtained after washing with dichloromethane.

Workup

  1. temperatureto reflux overnight
  2. customAver evaporation and crystallization of the oily residue

Sources & evidence

ORD record
ord-be580a30a9b34f9bbed5e1bf558fbc35
Source dataset
uspto-grants-1993_07
Patent number
US05229399

Reaction notes

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