Nitric Acid → 1-(3-Bromopropyl)-4-nitrobenzene

HRID 484072Notes

Reaction equation

HRID 484072 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.S(=O)(=O)(O)O.[N+:16]([O-])([OH:18])=[O:17]>>[Br:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N+:16]([O-:18])=[O:17])=[CH:7][CH:6]=1

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 12503(3-Bromopropyl)benzene

Product 1

HCID 104444821-(3-Bromopropyl)-4-nitrobenzeneYield 63.7%

Conditions

Temperature
60 °C

Procedure

1-Bromo-3-phenylpropane (19.7 mmol) was added slowly to a solution of sulfuric acid (7.4 g) and nitric acid (5.4 g) at ambient temperature and stirred at 60° C. The residue (mixture of ortho and para) was purified by column chromatography on silica gel. Yield 63.7%

Workup

  1. additionThe residue (mixture of ortho and para)
  2. customwas purified by column chromatography on silica gel

Sources & evidence

ORD record
ord-4fc31f28ff9d4a008239c8d0eff3dbdb
Source dataset
uspto-grants-1993_07
Patent number
US05229400

Reaction notes

Loading…