2-Aminoindane → 2-(2-Indanylamino)-1-thia-2,3,5,7-tetraazaindene

HRID 48408Notes

Reaction equation

HRID 48408 reaction equation
Cl[N:2]1[NH:10][C:9]2[C:4](=[N:5][CH:6]=[N:7][CH:8]=2)[S:3]1.[NH2:11][CH:12]1[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13]1>>[CH2:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:20][CH:12]1[NH:11][N:2]1[NH:10][C:9]2[C:4](=[N:5][CH:6]=[N:7][CH:8]=2)[S:3]1

Participants

3

Reactant 2

HCID 763102-AminoindaneHCID 227196192-Chloro-1-thia-2,3,5,7-tetraazaindene

Product 1

HCID 227196392-(2-Indanylamino)-1-thia-2,3,5,7-tetraazaindeneYield 51.7%

Procedure

Using 2-chloro-1-thia-2,3,5,7-tetraazaindene (50 mg, 0.29 mmol) (see J. Org. Chem. 26, 4961 (1961), J. Chem. Soc. (C) 1856 (1967)) and 2-aminoindan (120 mg, 0.90 mmol), a similar procedure to Production Example 190 was carried out. The product obtained was purified by silica gel chromatography (hexane:ethyl acetate=3:1) to obtain the title compound (41 mg, 0.15 mmol) having the following physical properties:

Workup

  1. customThe product obtained
  2. customwas purified by silica gel chromatography (hexane:ethyl acetate=3:1)

Sources & evidence

ORD record
ord-8f80ee803ed04db89c1d79578a7d8e16
Source dataset
uspto-grants-2004_03
Patent number
US06703421B1

Reaction notes

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